Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

@article{Yoo2007AtaxiatelangiectasiaM,
  title={Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.},
  author={Hae Yong Yoo and Akiko Kumagai and Anna Shevchenko and Andrej Shevchenko and William G. Dunphy},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 24},
  pages={17501-6}
}
ATM (ataxia-telangiectasia mutated) is necessary for activation of Chk1 by ATR (ATM and Rad3-related) in response to double-stranded DNA breaks (DSBs) but not to DNA replication stress. TopBP1 has been identified as a direct activator of ATR. We show that ATM regulates Xenopus TopBP1 by phosphorylating Ser-1131 and thereby strongly enhancing association of TopBP1 with ATR. Xenopus egg extracts containing a mutant of TopBP1 that cannot be phosphorylated on Ser-1131 are defective in the ATR… CONTINUE READING

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Cell 11, 203–213 ATM Activates ATR-ATRIP via TopBP1 17506 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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