Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

@article{Baskaran1997AtaxiaTM,
  title={Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation},
  author={Rajasekaran Baskaran and Lauren D. Wood and L L Whitaker and Christine E. Canman and Susan E. Morgan and Yang Xu and Carrolee Barlow and David Baltimore and Anthony Wynshaw-Boris and Michael B. Kastan and Jean Y. J. Wang},
  journal={Nature},
  year={1997},
  volume={387},
  pages={516-519}
}
Ataxia telangiectasia (AT) is a rare human autosomal recessive disorder with pleiotropic phenotypes, including neuronal degeneration, immune dysfunction, premature ageing and increased cancer risk. The gene mutated in AT, ATM, encodes a putative lipid or protein kinase1,2. Most of the human AT patient phenotypes are recapitulated in Atm-deficient mice3,4. Cells derived from Atm-/- mice, like those from AT patients, exhibit abnormal response to ionizing radiation3,5,6. One of the known responses… CONTINUE READING

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