Ataxia telangiectasia gene mutations in leukaemia and lymphoma.

  title={Ataxia telangiectasia gene mutations in leukaemia and lymphoma.},
  author={Jacqueline Boultwood},
  journal={Journal of clinical pathology},
  volume={54 7},
Ataxia telangiectasia (AT) is a rare multisystem, autosomal, recessive disease characterised by neuronal degeneration, genome instability, and an increased risk of cancer. Approximately 10% of AT homozygotes develop cancer, mostly of the lymphoid system. Lymphoid malignancies in patients with AT are of both B cell and T cell origin, and include Hodgkin's lymphoma, non-Hodgkin's lymphoma, and several forms of leukaemia. The AT locus was mapped to the chromosomal region 11q22-23 using genetic… CONTINUE READING


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The ATM gene in the pathogenesis of mantle-cell lymphoma.

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