Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor

@article{Matsumoto1996AtaxiaAE,
  title={Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor},
  author={Makoto Matsumoto and Terunaga Nakagawa and Tsutomu Inoue and Eiichiro Nagata and Kiyoji Tanaka and Hiroshi Takano and Junko Kuno and Shinichi Sakakibara and Masahisa Yamada and Hiroyuki Yoneshima and Atsushi Miyawaki and Yasuhiro Furuichi and Hideyuki Okano and Satoshi Mikoshiba and Tetsuo Noda},
  journal={Nature},
  year={1996},
  volume={379},
  pages={168-171}
}
THE inositol 1,4,5-trisphosphate (InsP3) receptor acts as an InsP3-gated Ca2+ release channel in a variety of cell types1,2. Type 1 InsP3 receptor (IP3R1) is the major neuronal member of the IP3R family in the central nervous system3,4, predominantly enriched in cerebellar Purkinje cells but also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex5,6. Here we report that most IP3R1-deficient mice generated by gene targeting die in utero, and born animals… CONTINUE READING
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