AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana.

@article{Muyt2007AtPRD1IR,
  title={AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana.},
  author={Arnaud De Muyt and Daniel Vezon and Ghislaine Gendrot and Jean-Luc Gallois and Rebecca Stevens and Mathilde Grelon},
  journal={The EMBO journal},
  year={2007},
  volume={26 18},
  pages={4126-37}
}
The initiation of meiotic recombination by the formation of DNA double-strand breaks (DSBs) catalysed by the Spo11 protein is strongly evolutionary conserved. In Saccharomyces cerevisiae, Spo11 requires nine other proteins for meiotic DSB formation, but, unlike Spo11, few of these proteins seem to be conserved across kingdoms. In order to investigate this recombination step in higher eukaryotes, we have isolated a new gene, AtPRD1, whose mutation affects meiosis in Arabidopsis thaliana. In… CONTINUE READING
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