At the Biological Modeling and Simulation Frontier

  title={At the Biological Modeling and Simulation Frontier},
  author={C. Anthony Hunt and Glen E. P. Ropella and Tai Ning Lam and Jonathan Tang and Sean H. J. Kim and Jesse Engelberg and Shahab Sheikh-Bahaei},
  booktitle={Pharmaceutical Research},
We provide a rationale for and describe examples of synthetic modeling and simulation (M&S) of biological systems. We explain how synthetic methods are distinct from familiar inductive methods. Synthetic M&S is a means to better understand the mechanisms that generate normal and disease-related phenomena observed in research, and how compounds of interest interact with them to alter phenomena. An objective is to build better, working hypotheses of plausible mechanisms. A synthetic model is an… CONTINUE READING