At low pH, influenza virus matrix protein M1 undergoes a conformational change prior to dissociating from the membrane.

@article{Fontana2013AtLP,
  title={At low pH, influenza virus matrix protein M1 undergoes a conformational change prior to dissociating from the membrane.},
  author={Juan Fontana and Alasdair C. Steven},
  journal={Journal of virology},
  year={2013},
  volume={87 10},
  pages={5621-8}
}
The M1 matrix protein of influenza A virus, which plays multiple roles in virion assembly and infection, underlies the viral envelope. However, previous studies have given differing accounts of the number of layers in the M1-envelope complex and their thicknesses and compositions. To resolve this issue, we performed cryo-electron microscopy and cryo-electron tomography on the self-same specimens. At neutral pH, there were two kinds of complexes, corresponding to a lipid bilayer with embedded… CONTINUE READING

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