At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation.

@article{Zhou2009AtLC,
  title={At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation.},
  author={Wenbo Zhou and Amy M. Gallagher and Dong-Pyo Hong and Chunmei Long and Anthony L. Fink and Vladimir N. Uversky},
  journal={Journal of molecular biology},
  year={2009},
  volume={388 3},
  pages={
          597-610
        }
}
Several studies have shown that catecholamines can inhibit the fibrillation of alpha-synuclein (alpha-Syn), a small presynaptic protein whose aggregation is believed to be a critical step in the etiology of Parkinson's disease and several other neurodegenerative disorders. However, the mechanism of this inhibition is uncertain. We show here that substoichiometric concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC), a normal product of the metabolism of dopamine, can inhibit the… CONTINUE READING
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