At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.

@article{Goldsmith1988AtLT,
  title={At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.},
  author={Mark Goldsmith and Paul F. Dazin and Arthur Weiss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 22},
  pages={8613-7}
}
In the T-cell somatic mutant J.CaM1, the T-cell antigen receptor complex is poorly coupled to the inositolphospholipid second messenger system; some antibodies against the invariant CD3 subunit of the receptor retain their agonist function in J.CaM1. Here we show by a combination of complementation assays that the mutation in J.CaM1 affects a molecule other than the antigen-binding Ti subunit, suggesting that Ti is coupled indirectly to the signal transduction apparatus through a pathway… CONTINUE READING
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