Asynchronous replication dynamics of imprinted and non-imprinted chromosome regions in early mouse embryos.

@article{May2008AsynchronousRD,
  title={Asynchronous replication dynamics of imprinted and non-imprinted chromosome regions in early mouse embryos.},
  author={Andreas Balser May and Kurt Reifenberg and Ulrich Zechner and Thomas Haaf},
  journal={Experimental cell research},
  year={2008},
  volume={314 15},
  pages={2788-95}
}
We have used interphase FISH to analyze the replication behavior of four imprinted chromosome regions (Snrpn, Zim1-Peg3, Dlk1-Gtl2, and Igf2r) and five non-imprinted regions in mouse one-cell to morula-stage embryos and embryonic fibroblasts. In general, imprinted chromosome regions showed the expected asynchronous pattern of replication throughout all analyzed stages of preimplantation development and in differentiated cells. The Dlk1-Gtl2 locus which is not expressed and Igf2r which is… CONTINUE READING