Asynchronous electrical activation induces asymmetrical hypertrophy of the left ventricular wall.

@article{Oosterhout1998AsynchronousEA,
  title={Asynchronous electrical activation induces asymmetrical hypertrophy of the left ventricular wall.},
  author={Matthijs F. M. van Oosterhout and Frits W. Prinzen and Theo Arts and Jan J. Schreuder and Ward Y R Vanagt and Jack P. M. Cleutjens and Robert S. Reneman},
  journal={Circulation},
  year={1998},
  volume={98 6},
  pages={588-95}
}
BACKGROUND Asynchronous electrical activation, induced by ventricular pacing, causes regional differences in workload, which is lower in early- than in late-activated regions. Because the myocardium usually adapts its mass and structure to altered workload, we investigated whether ventricular pacing leads to inhomogeneous hypertrophy and whether such adaptation, if any, affects global left ventricular (LV) pump function. METHODS AND RESULTS Eight dogs were paced at physiological heart rate… CONTINUE READING

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