Asymptotic properties of affected-sib-pair linkage analysis.

  title={Asymptotic properties of affected-sib-pair linkage analysis.},
  author={Peter Holmans},
  journal={American journal of human genetics},
  volume={52 2},
  • Peter Holmans
  • Published 1993 in American journal of human genetics
The likelihood-ratio method for affected-sib-pair analysis, introduced by Risch, is a powerful method for detecting linkage when the marker is not perfectly polymorphic, as is often the case. The power of this method can be improved by restricting maximization to the set of possible haplotype-sharing probabilities--denoted the "possible triangle" method. The asymptotic distributions of the resulting distributions are derived, enabling test criteria to be found for any required test size (i.e… CONTINUE READING
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