Asymptotic analysis of microtubule-based transport by multiple identical molecular motors.

@article{McKinley2012AsymptoticAO,
  title={Asymptotic analysis of microtubule-based transport by multiple identical molecular motors.},
  author={Scott A. McKinley and Avanti Athreya and John Fricks and Peter R. Kramer},
  journal={Journal of theoretical biology},
  year={2012},
  volume={305},
  pages={
          54-69
        }
}
  • Scott A. McKinley, Avanti Athreya, +1 author Peter R. Kramer
  • Published 2012
  • Medicine, Mathematics, Biology, Physics
  • Journal of theoretical biology
  • We describe a system of stochastic differential equations (SDEs) which model the interaction between processive molecular motors, such as kinesin and dynein, and the biomolecular cargo they tow as part of microtubule-based intracellular transport. We show that the classical experimental environment fits within a parameter regime which is qualitatively distinct from conditions one expects to find in living cells. Through an asymptotic analysis of our system of SDEs, we develop a means for… CONTINUE READING

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