Asymptomatic progressive multifocal leukoencephalopathy associated with natalizumab

@article{Govern2012AsymptomaticPM,
  title={Asymptomatic progressive multifocal leukoencephalopathy associated with natalizumab},
  author={Eavan Mary Mc Govern and Michael Joseph Hennessy},
  journal={Journal of Neurology},
  year={2012},
  volume={260},
  pages={665-667}
}
Progressive multifocal leukoencephalopathy (PML), first described on postmortem studies in 1958 [1], is an opportunistic brain infection caused by JC virus, and a potential fatal complication of natalizumab therapy [2]. However, natalizumab remains one of the most efficacious treatments for relapsing remitting multiple sclerosis, reducing the annual rate of relapse by 68 % [3]. Therefore, ongoing patient monitoring and early detection of this serious complication is of paramount importance to… CONTINUE READING
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