Asymmetry of substantia nigra neuronal loss in Parkinson's disease and its relevance to the mechanism of levodopa related motor fluctuations.

@article{Kempster1989AsymmetryOS,
  title={Asymmetry of substantia nigra neuronal loss in Parkinson's disease and its relevance to the mechanism of levodopa related motor fluctuations.},
  author={P. A. Kempster and W. R. G. Gibb and Gerald M. Stern and Andrew John Lees},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={1989},
  volume={52},
  pages={72 - 76}
}
A pathological study of 21 patients with Parkinson's disease of asymmetrical onset revealed significant asymmetry of degeneration of the substantia nigra with greater neuronal loss contralateral to the initially affected body side. It has previously been suggested that decline in duration of effectiveness of levodopa doses in Parkinsonian patients with motor oscillations is caused by loss of nigro-striatal dopaminergic terminals with consequent reduction in striatal dopamine storage capacity… Expand
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