Asymmetry in RNA pseudoknots: observation and theory

@article{Aalberts2005AsymmetryIR,
  title={Asymmetry in RNA pseudoknots: observation and theory},
  author={Daniel P. Aalberts and Nathan O. Hodas},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={2210 - 2214}
}
RNA can fold into a topological structure called a pseudoknot, composed of non-nested double-stranded stems connected by single-stranded loops. Our examination of the PseudoBase database of pseudoknotted RNA structures reveals asymmetries in the stem and loop lengths and provocative composition differences between the loops. By taking into account differences between major and minor grooves of the RNA double helix, we explain much of the asymmetry with a simple polymer physics model and… CONTINUE READING

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