Asymmetry-defective oligodendrocyte progenitors are glioma precursors.


Postnatal oligodendrocyte progenitor cells (OPC) self-renew, generate mature oligodendrocytes, and are a cellular origin of oligodendrogliomas. We show that the proteoglycan NG2 segregates asymmetrically during mitosis to generate OPC cells of distinct fate. NG2 is required for asymmetric segregation of EGFR to the NG2(+) progeny, which consequently… (More)
DOI: 10.1016/j.ccr.2011.08.011


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