Asymmetry across species

@article{Jan1999AsymmetryAS,
  title={Asymmetry across species},
  author={Yuh Nung Jan and Lily Yeh Jan},
  journal={Nature Cell Biology},
  year={1999},
  volume={1},
  pages={E42-E44}
}
  • Y. JanL. Jan
  • Published 1 June 1999
  • Biology
  • Nature Cell Biology
In both worms and flies, asymmetric cell divisions involve the protein Bazooka/PAR-3, which is required for the asymmetric segregation of cell-fate determinants. However, differential distribution of a determinant between daughter cells may be achieved by different means in alternative developmental settings. 

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Changes of regularity (eutacticity) in a macroevolutive and taxonomic level of sea urchins belonging to the Echinoidea class suggests a high degree ofregularity in the shape of these organisms through their evolution.

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  • 2003

References

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Insight is gained into the cellular mechanisms by which these determinants are preferentially segregated into one of the two daughter cells during mitosis so that the daughter cells acquire different fates.

Role of inscuteable in orienting asymmetric cell divisions in Drosophila

Drosophila neuroblasts and epithelial cells in the procephalic neurogenic region divide perpendicular to the surface, and segregate the proteins Numb and Prospero into the basal daughter cell. We

Asymmetric segregation of the homeodomain protein Prospero duringDrosophila development

It is proposed that asymmetric segregation of transcription factors is an intrinsic mechanism for establishing asymmetry in gene expression between sibling cells in the Drosophilacentral nervous system.

Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch.

It is shown that the homeodomain transcription factor Prospero (Pros) acts as an intrinsic signal for the specification of cell fates within the mechanosensory lineage.

Asymmetric cell division: from A to Z.

This work focuses on asymmetric cell divisions that occur during the development of the Caenorhabditis elegans and Drosophila nervous systems and indicates that a combination of intrinsic and extrinsic mechanisms specify distinct daughter cell fates during asymmetriccell divisions.

Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage.

Investigation of the expression and function of prospero in the adult SOP lineage concludes that prospero plays a fundamental role in establishing binary IIa/IIb sibling cell fates without being asymmetrically localized during SOP division.