Asymmetrical electrically induced injury of rabbit ventricular myocytes.

  title={Asymmetrical electrically induced injury of rabbit ventricular myocytes.},
  author={S. B. Knisley and Augustus O. Grant},
  journal={Journal of molecular and cellular cardiology},
  volume={27 5},
Strong defibrillation-type electric field stimulation may injure myocytes when transmembrane potentials during the pulse exceed the threshold for membrane permeabilization. The location of injury may depend on intrinsic transmembrane potential or influx of calcium by "electro-osmosis" during the stimulation pulse in addition to the transmembrane potential changes induced by the pulse. We have studied injury by examining contracture and changes in transmembrane potential-sensitive dye… CONTINUE READING