Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases.

@article{Bae2010AsymmetricTK,
  title={Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases.},
  author={Jae Hyun Bae and Joseph Schlessinger},
  journal={Molecules and cells},
  year={2010},
  volume={29 5},
  pages={443-8}
}
Receptor tyrosine kinases (RTKs) play important roles in the control of many cellular processes including cell proliferation, cell adhesion, angiogenesis, and apoptosis. Ligand-induced dimerization of RTKs leads to autophosphorylation and activation of RTKs. Structural studies have shown that while isolated ectodomains of several RTKs form symmetric dimers the isolated cytoplasmic kinase domains of epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor (FGFR) form… CONTINUE READING