Asymmetric transfer hydrogenation of ketones catalyzed by rhodium complexes containing amino acid triazole ligands.

Abstract

Active and selective catalysts for the asymmetric reduction of ketones, under transfer hydrogenation conditions, were obtained by combining [RhCl(2)Cp*](2), with a series of l-amino acid thioamide ligands functionalized with 1,2,3-triazoles. The obtained secondary alcohol products were formed with up to 93% ee. 
DOI: 10.1039/c0ob00400f

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