Asymmetric total synthesis of (+)-attenol B.


The more cytotoxic, thermodynamically less stable (+)-attenol B was isolated as a minor isomer of the spiroketal attenol A and synthesized previously as a minor product. Herein, we report a new strategy that for the first time led to asymmetric synthesis of (+)-attenol B as an exclusive product, featuring sequential Achmatowicz rearrangement… (More)
DOI: 10.1021/acs.orglett.5b00038


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