Asymmetric total synthesis and antiproliferative activity of goniothalamin oxide isomers.

@article{Marquissolo2009AsymmetricTS,
  title={Asymmetric total synthesis and antiproliferative activity of goniothalamin oxide isomers.},
  author={Cilene Marquissolo and {\^A}ngelo de F{\'a}tima and Luciana Konecny Kohn and Ana L{\'u}cia Tasca Gois Ruiz and Jo{\~a}o Ernesto de Carvalho and Ronaldo Aloise Pilli},
  journal={Bioorganic chemistry},
  year={2009},
  volume={37 2},
  pages={
          52-6
        }
}
Isolation and biotransformation of goniothalamin in the production of goniothalamin analogue
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The purpose of this study is to synthesise goniothalamin derivatives via biotransformation of goni hypothalamin using an enzyme assay to obtain an analogue with dihydro functionality.
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This review covers the chemistry and biological aspects of goniothalamin-related styryl lactones isolated from natural sources and the reports on the synthesis, biological activity and mechanism of action which were published from 2007-2017.
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Six previously undescribed diastereomers showed cytotoxic activity against human colon and lung cancer cell lines with IC50 values ranging from 2.38–7.59 μM and 6S-goniothalamin 1 is reported for the first time from a Goniothalamus species.
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Asymmetric synthesis of (–)-leiocarpin A via (–)-(S)-goniothalamin employing Julia–Kocienski olefination
ABSTRACT A concise and enantioselective syntheses of antileukemic natural products such as (–)-(S)-goniothalamin and (–)-leiocarpin A has been accomplished in excellent yields. By employing reported
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References

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Styrylpyrone Derivatives From Goniothalamus dolichocarpus
Styrylpyrone derivatives (+)-goniothalamin (1), (+)-goniothalamin epoxide (2) and (–)-iso-5-deoxygoniopypyrone (4b), and the acetogenin (+)-annonacin (7) were bioactive compounds isolated from the
Cytotoxic styrylpyrones from Goniothalamus amuyon
Two new styrylpyrones, (6R,7R,8R)-8-methoxygoniodiol (1) and (6R,7R,8R)-8-chlorogoniodiol (2), together with seven known styrylpyrones and eight other known compounds, were isolated from the leaves
Styryl lactones and their derivatives: biological activities, mechanisms of action and potential leads for drug design.
TLDR
The biological activities of styryl lactones focusing on cancer cells, the causal agent of Chagas' disease and the vectors for yellow fever and human lymphatic filariasis are discussed, as well as immunosuppressive and inflammatory processes.
A Concise Enantioselective Strategy to (+)-(R)-Goniothalamin and (+)-(R)-Goniothalamin Oxide by Employing Hydrolytic Kinetic Resolution and Ring-Closing Metathesis as Key Steps
TLDR
(R)-Goniothalamin oxide was prepared in high yield and diastereomeric excess under various epoxidation conditions and described by using Jacobsen's hydrolytic kinetic resolution of racemic epoxide and ring-closing metathesis as key steps.
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