Asymmetric synthesis with boronic esters

Abstract

Reaction of (dichloromethyl)lithium with (+)—pinanediol alkylboronates at —100 °C folloed by treatment with anhydrous zinc chloride and warming to 0—25 C results in insertion of a chloromethyl group into the carbon—boron bond to increase the chain length by one carbon and form (l)—l—chloroalkylboronic esters in 85—99Z yields and usually 99Z or better… (More)

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