Asymmetric synthesis of (-)-swainsonine.


We report a new asymmetric synthetic method for (-)-swainsonine utilizing a chiral oxazoline precursor. The key features in this strategy are the diastereoselective oxazoline formation reaction catalyzed by palladium(0), diasteroselective dihydroxylation, and the stereocontrolled allylation reaction with TiCl(4).

DOI: 10.1021/jo802800d

Cite this paper

@article{Tian2009AsymmetricSO, title={Asymmetric synthesis of (-)-swainsonine.}, author={Yong-Shou Tian and Jae-Eun Joo and Bae-Soo Kong and V Pham and Kee-Young Lee and Won-Hun Ham}, journal={The Journal of organic chemistry}, year={2009}, volume={74 10}, pages={3962-5} }