Asymmetric synthesis of planar chiral ferrocenes by enantioselective intramolecular C-H arylation of N-(2-haloaryl)ferrocenecarboxamides.

@article{Liu2014AsymmetricSO,
  title={Asymmetric synthesis of planar chiral ferrocenes by enantioselective intramolecular C-H arylation of N-(2-haloaryl)ferrocenecarboxamides.},
  author={Lantao Liu and An-An Zhang and Rui-Juan Zhao and Feng Li and Tuan-Jie Meng and Naoki Ishida and Masahiro Murakami and Wen-Xian Zhao},
  journal={Organic letters},
  year={2014},
  volume={16 20},
  pages={5336-8}
}
The palladium-catalyzed intramolecular C-H arylation reaction of N-(2-bromoaryl)ferrocenecarboxamides furnishes planar chiral ferrocene derivatives. TADDOL-derived phosphoramide ligands induce enantioselectivities ranging from 91:9 to 98:2 er.