Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid.

Abstract

A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92 : 8 er. 
DOI: 10.1039/c7ob01527e

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