Asymmetric synthesis of functionalized 1,3-diphosphines via chiral palladium complex promoted hydrophosphination of activated olefins.


Aldehyde, ester- and keto-functionalized monophosphine palladium complexes containing the ortho-metalated (R)-(1-(dimethylamino)ethyl)naphthalene as the chiral auxiliary and reaction promoter were synthesized via hydrophosphination of acrolein and the subsequent Wittig reactions in a one-pot process. Under very mild conditions, the second-stage… (More)
DOI: 10.1021/ic9018053


7 Figures and Tables