Asymmetric synthesis of emericellamide B

  title={Asymmetric synthesis of emericellamide B},
  author={Rong‐Guo Ren and Jing-yi Ma and Zhuo-Ya Mao and Yi-Wen Liu and Bang-Guo Wei},
  journal={Chinese Chemical Letters},
Asymmetric total synthesis of emericellamide B (9.4%, 17 longest linear steps) is detailed in this report. In this synthetic route, the highly methylated (2R,3R,4S,6S)-3-hydroxy-2,4,6-trimethyldodecanoic acid (HTMD) unit was effectively prepared through the asymmetric methylation, Wittig and Horner–Wadsworth–Emmons reaction. Moreover, pentafluorophenyl diphenylphophinate (FDPP) proved to be an effective condensation reagent for the macrolactamization between C14 and C18. 
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