Asymmetric synthesis of 3-hydroxy-pyrrolidines via tin-lithium exchange and cyclization.

Abstract

We report a method for the synthesis of chiral pyrrolidines using tin-lithium exchange and cyclization reactions. The precursors are formed readily from simple starting materials and undergo tin-lithium exchange by treatment with n-butyllithium. Subsequent intramolecular carbolithiation is stereoselective to give highly enantiomerically enriched… (More)

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@article{Christoph2006AsymmetricSO, title={Asymmetric synthesis of 3-hydroxy-pyrrolidines via tin-lithium exchange and cyclization.}, author={Guido Christoph and Christian Stratmann and Iain Coldham and Dieter Hoppe}, journal={Organic letters}, year={2006}, volume={8 20}, pages={4469-71} }