Asymmetric sulfa-Michael addition to α-substituted vinyl ketones catalyzed by chiral primary amine.

@article{Fu2014AsymmetricSA,
  title={Asymmetric sulfa-Michael addition to α-substituted vinyl ketones catalyzed by chiral primary amine.},
  author={Niankai Fu and Long Zhang and Sanzhong Luo and Jin-Pei Cheng},
  journal={Organic letters},
  year={2014},
  volume={16 17},
  pages={4626-9}
}
The first effective example of asymmetric conjugate addition-protonation reactions of thiols to α-substituted vinyl ketones by chiral primary amine catalysis is reported. A simple chiral primary-tertiary diamine catalyst derived from l-phenylalanine was found to promote the sulfa-Michael addition-protonation reactions with good to excellent… CONTINUE READING