Asymmetric structure of the cystic fibrosis transmembrane conductance regulator chloride channel pore suggested by mutagenesis of the twelfth transmembrane region.

@article{Gupta2001AsymmetricSO,
  title={Asymmetric structure of the cystic fibrosis transmembrane conductance regulator chloride channel pore suggested by mutagenesis of the twelfth transmembrane region.},
  author={J. Sen Gupta and Alexandra Evagelidis and John W. Hanrahan and Paul Linsdell},
  journal={Biochemistry},
  year={2001},
  volume={40 22},
  pages={6620-7}
}
The cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel contains 12 membrane-spanning regions which are presumed to form the transmembrane pore. Although a number of findings have suggested that the sixth transmembrane region plays a key role in forming the pore and determining its functional properties, the role of other transmembrane regions is currently not well established. Here we assess the functional importance of the twelfth transmembrane region, which occupies a… CONTINUE READING

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