Asymmetric stem cell division in development and cancer.

@article{Caussinus2007AsymmetricSC,
  title={Asymmetric stem cell division in development and cancer.},
  author={Emmanuel Caussinus and Frank Hirth},
  journal={Progress in molecular and subcellular biology},
  year={2007},
  volume={45},
  pages={205-25}
}
Asymmetric stem cell division leads to another stem cell via self-renewal, and a second cell type which can be either a differentiating progenitor or a postmitotic cell. The regulation of this balanced process is mainly achieved by polarization of the stem cell along its apical-basal axis and the basal localization and asymmetric segregation of cell fate determinants solely to the differentiating cell. It has long been speculated that disturbance of this process can induce a cancer-like state… CONTINUE READING

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