Asymmetric stem cell division in development and cancer.

  title={Asymmetric stem cell division in development and cancer.},
  author={Emmanuel Caussinus and Frank Hirth},
  journal={Progress in molecular and subcellular biology},
Asymmetric stem cell division leads to another stem cell via self-renewal, and a second cell type which can be either a differentiating progenitor or a postmitotic cell. The regulation of this balanced process is mainly achieved by polarization of the stem cell along its apical-basal axis and the basal localization and asymmetric segregation of cell fate determinants solely to the differentiating cell. It has long been speculated that disturbance of this process can induce a cancer-like state… CONTINUE READING


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