Asymmetric segregation of Numb in retinal development and the influence of the pigmented epithelium.

@article{Cayouette2001AsymmetricSO,
  title={Asymmetric segregation of Numb in retinal development and the influence of the pigmented epithelium.},
  author={Michel Cayouette and A. V. Whitmore and Glen Jeffery and Martin J. Raff},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 15},
  pages={5643-51}
}
Asymmetric segregation of cell-fate determinants during cytokinesis plays an important part in controlling cell-fate choice in invertebrates. During Drosophila neurogenesis, for example, asymmetric segregation of the Numb protein, which inhibits Notch signaling, is necessary for the two daughter cells of a division to have different fates. In vertebrates… CONTINUE READING