Asymmetric radical addition of ethers to enantiopure N-p-toluenesulfinyl aldimines, mediated by dimethylzinc-air.

@article{Akindele2006AsymmetricRA,
  title={Asymmetric radical addition of ethers to enantiopure N-p-toluenesulfinyl aldimines, mediated by dimethylzinc-air.},
  author={Tito Akindele and Yasutomo Yamamoto and Masaru Maekawa and Hiroyuki Umeki and Ken-ichi Yamada and Kiyoshi Tomioka},
  journal={Organic letters},
  year={2006},
  volume={8 25},
  pages={5729-32}
}
Asymmetric radical addition of ethers to enantiopure aromatic N-p-toluenesulfinyl aldimines has been achieved. The requisite radicals were generated by dimethylzinc-air. Lewis acid activation of the N-p-toluenesulfinyl aldimines followed by radical addition gives a mixture of sulfinamide and sulfonamide products. Subsequent treatment of the mixture with dry… CONTINUE READING