Asymmetric protein localization in planar cell polarity: mechanisms, puzzles, and challenges.

@article{Peng2012AsymmetricPL,
  title={Asymmetric protein localization in planar cell polarity: mechanisms, puzzles, and challenges.},
  author={Y. N. Peng and Jeffrey D. Axelrod},
  journal={Current topics in developmental biology},
  year={2012},
  volume={101},
  pages={33-53}
}
The polarization of epithelial cells along an axis orthogonal to their apical-basal axis is increasingly recognized for roles in a variety of developmental events and physiological functions. While now studied in many model organisms, mechanistic understanding is rooted in intensive investigations of planar cell polarity (PCP) in Drosophila. Consensus has emerged that two molecular modules, referred to here as the global and core modules, operate upstream of effector proteins to produce… CONTINUE READING
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