Asymmetric pitx2 expression in medaka epithalamus is regulated by nodal signaling through an intronic enhancer

@article{Soukup2018AsymmetricPE,
  title={Asymmetric pitx2 expression in medaka epithalamus is regulated by nodal signaling through an intronic enhancer},
  author={Vladimir Soukup and Simona Mrstakova and Zbyněk Kozm{\'i}k},
  journal={Development Genes and Evolution},
  year={2018},
  volume={228},
  pages={131-139}
}
The epithalamic region of fishes shows prominent left-right asymmetries that are executed by nodal signaling upstream of the asymmetry-determining transcription factor pitx2. Previous reports have identified that nodal controls the left-sided pitx2 expression in the lateral plate mesoderm through an enhancer present in the last intron of this gene. However, whether similar regulation occurs also in the case of epithalamic asymmetry is currently unresolved. Here, we address some of the cis… CONTINUE READING
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