Asymmetric mitotic segregation of the yeast spindle pole body

@article{Vallen1992AsymmetricMS,
  title={Asymmetric mitotic segregation of the yeast spindle pole body},
  author={Elizabeth Ann Vallen and T Y Scherson and Tom Roberts and Karen van der Zee and Mark D Rose},
  journal={Cell},
  year={1992},
  volume={69},
  pages={505-515}
}
The yeast KAR1 gene is required for spindle pole body (SPB) duplication and nuclear fusion. We determine here that KAR1-beta-galactosidase hybrid proteins localize to the outer face of the SPB. Remarkably, after SPB duplication, the hybrid protein was found associated with only one of the two SPBs, usually the one that enters the bud. Using an ndc1 mutant, which forms a defective SPB at the nonpermissive temperature, we found that the hybrid was exclusively associated with the "new" SPB. Two… CONTINUE READING

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