Asymmetric membrane ganglioside sialidase activity specifies axonal fate

@article{Silva2005AsymmetricMG,
  title={Asymmetric membrane ganglioside sialidase activity specifies axonal fate},
  author={Jorge Santos Da Silva and Takafumi Hasegawa and Taeko Miyagi and Carlos G Dotti and Jos{\'e} Abad-Rodr{\'i}guez},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={606-615}
}
Axon specification triggers the polarization of neurons and requires the localized destabilization of filamentous actin. Here we show that plasma membrane ganglioside sialidase (PMGS) asymmetrically accumulates at the tip of one neurite of the unpolarized rat neuron, inducing actin instability. Suppressing PMGS activity blocks axonal generation, whereas stimulating it accelerates the formation of a single (not several) axon. PMGS induces axon specification by enhancing TrkA activity locally… 
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