Corpus ID: 14124611

Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS.

@article{Spana1995AsymmetricLO,
  title={Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS.},
  author={Eric P. Spana and Casey Kopczynski and Corey S. Goodman and Chris Q. Doe},
  journal={Development},
  year={1995},
  volume={121 11},
  pages={
          3489-94
        }
}
  • Eric P. Spana, Casey Kopczynski, +1 author Chris Q. Doe
  • Published in Development 1995
  • Biology, Medicine
  • The central nervous system (CNS) represents an excellent model system for examining how a multitude of unique cell fates are specified. We find that asymmetric localization of the numb protein autonomously controls a binary cell fate decision in the Drosophila CNS. The simplest lineage in the Drosophila CNS is that of the MP2 precursor: it divides unequally to generate the dMP2 and vMP2 neurons. Both are interneurons but project in different directions: dMP2 projects its axon posteriorly while… CONTINUE READING

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