Asymmetric induction in acyclic systems utilizing metal compounds

  title={Asymmetric induction in acyclic systems utilizing metal compounds},
  author={Koichi Narasaka},
Stereochemistry of the reduction of acyclic 13-hydroxy ketones and their O—benzyloximes is well directed by a hydroxyl group to give syn— 1,3—diols and syn—1,3—amino alcohols respectively. Furtiermore, a highly enantioselective aldol reaction is achieved starting from chiral 1,3— oxazolidines prepared from ketones and chiral norephedrine. Generation of stannous azaenolate from the oxazolidines and the successive reaction with aldehydes lead to the aldol products in high level of enantiomeric… CONTINUE READING