Asymmetric hydrogenation via architectural and functional molecular engineering*


RuCl2(phosphine)2(1,2-diamine) complexes, coupled with an alkaline base in 2-propanol, allows for preferential hydrogenation of a C=O function over coexisting conjugated or nonconjugated C=C linkages, a nitro group, halogen atoms, and various heterocycles. The functional group selectivity is based on the novel metal–ligand bifunctional mechanism. The use of… (More)