Asymmetric hydrogenation of isobutyrophenone using a [(Diphosphine) RuCl2 (1,4-diamine)] catalyst.

@article{Grasa2005AsymmetricHO,
  title={Asymmetric hydrogenation of isobutyrophenone using a [(Diphosphine) RuCl2 (1,4-diamine)] catalyst.},
  author={G. Grasa and A. Zanotti-Gerosa and J. Medlock and W. Hems},
  journal={Organic letters},
  year={2005},
  volume={7 8},
  pages={
          1449-51
        }
}
  • G. Grasa, A. Zanotti-Gerosa, +1 author W. Hems
  • Published 2005
  • Chemistry, Medicine
  • Organic letters
  • [reaction: see text] The use of three chiral 1,4-diamines in the [(diphosphine) RuCl(2) (diamine)] catalyst system is demonstrated in the hydrogenation of acetophenone. The use of a 1,4-diamine offers unique properties that allow tuning of the catalyst system. These include the first example of the use of a racemic diamine in combination with a chiral phosphine, which gives 95% ee in the hydrogenation of isobutyrophenone. 
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