Asymmetric first total syntheses and assignment of absolute configuration of oxazinin-5, oxazinin-6 and preoxazinin-7.

@article{Dethe2011AsymmetricFT,
  title={Asymmetric first total syntheses and assignment of absolute configuration of oxazinin-5, oxazinin-6 and preoxazinin-7.},
  author={Dattatraya H Dethe and Alok Ranjan and Vijendra H. Pardeshi},
  journal={Organic & biomolecular chemistry},
  year={2011},
  volume={9 23},
  pages={
          7990-2
        }
}
  • Dattatraya H Dethe, Alok Ranjan, Vijendra H. Pardeshi
  • Published 2011
  • Chemistry, Medicine
  • Organic & biomolecular chemistry
  • Asymmetric first total syntheses of the unprecedented toxins oxazinin-5, oxazinin-6 and preoxazinin-7 have been achieved from a common key intermediate 18, derived from a regiocontrolled Sharpless asymmetric aminohydroxylation and oxa-Michael reaction, which in addition to confirming the structure also established the absolute configuration of the natural products. On the way an expeditious synthesis of a metabolite bursatellin was completed in 8 steps. 
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