Asymmetric fate of the posterior part of the second heart field results in unexpected left/right contributions to both poles of the heart.

@article{Domnguez2012AsymmetricFO,
  title={Asymmetric fate of the posterior part of the second heart field results in unexpected left/right contributions to both poles of the heart.},
  author={Jorge N Dom{\'i}nguez and Sigolene M. Meilhac and Yvette S Bland and Margaret E. Buckingham and Nigel Brown},
  journal={Circulation research},
  year={2012},
  volume={111 10},
  pages={1323-35}
}
RATIONALE The second heart field (SHF) contains progenitors of all heart chambers, excluding the left ventricle. The SHF is patterned, and the anterior region is known to be destined to form the outflow tract and right ventricle. OBJECTIVE The aim of this study was to map the fate of the posterior SHF (pSHF). METHODS AND RESULTS We examined the contribution of pSHF cells, labeled by lipophilic dye at the 4- to 6-somite stage, to regions of the heart at 20 to 25 somites, using mouse embryo… CONTINUE READING
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