Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure

Abstract

During Drosophila melanogaster dorsal closure, lateral sheets of embryonic epidermis assemble an actomyosin cable at their leading edge and migrate dorsally over the amnioserosa, converging at the dorsal midline. We show that disappearance of the homophilic cell adhesion molecule Echinoid (Ed) from the amnioserosa just before dorsal closure eliminates… (More)
DOI: 10.1083/jcb.201009022

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