Asymmetric direct vinylogous aldol reaction of unactivated gamma-butenolide to aldehydes.

Abstract

The asymmetric direct vinylogous aldol reaction of unactivated gamma-butenolide with aldehydes has been developed, giving the corresponding 5-(1'-hydroxy)butenolide derivatives in high yields (up to 93%) and enantioselectivities (up to 83% ee) under mild conditions.

DOI: 10.1021/jo100946d

Cite this paper

@article{Yang2010AsymmetricDV, title={Asymmetric direct vinylogous aldol reaction of unactivated gamma-butenolide to aldehydes.}, author={Yang Yang and Ke Zheng and Jiannan Zhao and Jian Shi and Lili Lin and Xiaohua Liu and Xiaoming Feng}, journal={The Journal of organic chemistry}, year={2010}, volume={75 15}, pages={5382-4} }