Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction.

@article{Sud2008AsymmetricDI,
  title={Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction.},
  author={Neetu Sud and Sandra M. Wells and Shruti Sharma Sharma and Dean Allen Wiseman and Jason Michael Wilham and S. M. Black},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={294 6},
  pages={
          C1407-18
        }
}
Increased asymmetric dimethylarginine (ADMA) levels have been implicated in the pathogenesis of a number of conditions affecting the cardiovascular system. However, the mechanism(s) by which ADMA exerts its effect has not been adequately elucidated. Thus the purpose of this study was to determine the effect of increased ADMA on nitric oxide (NO) signaling and to begin to elucidate the mechanism by which ADMA acts. Our initial data demonstrated that ADMA increased NO synthase (NOS) uncoupling in… CONTINUE READING

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