Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease

@article{Ueda2007AsymmetricD,
  title={Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease},
  author={Seiji Ueda and Sho-ichi Yamagishi and Yuriko Matsumoto and Kei Fukami and Seiya Okuda},
  journal={Clinical and Experimental Nephrology},
  year={2007},
  volume={11},
  pages={115-121}
}
Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD). NO is synthesized from L-arginine via the action of NO synthase, which is blocked by endogenous L-arginine analogues such as asymmetric dimethylarginine (ADMA). ADMA is a naturally occurring amino acid found in plasma and various types of tissues. The plasma level of ADMA is reported to be associated with… CONTINUE READING
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