Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond.

  title={Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond.},
  author={Rainer H. Boeger},
  journal={Annals of medicine},
  volume={38 2},
There is abundant evidence that the endothelium plays a crucial role in the maintenance of vascular tone and structure. One of the major endothelium-derived vasoactive mediators is nitric oxide (NO), an endogenous messenger molecule formed in healthy vascular endothelium from the amino acid precursor L-arginine. Endothelial dysfunction is caused by various cardiovascular risk factors, metabolic diseases, and systemic or local inflammation. One mechanism that explains the occurrence of… CONTINUE READING
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